Circulatory system disease, primarily caused by atherosclerosis, is the primarly cause of the #1, 3, and 13 killers in the United States: Heart disease, stroke and hypertension. Circulatory disease is also directly correlated to the incidence of the #6, 9 and 12 killers in the US: Diabetes, kidney and liver disease. While each of these diseases require specific nutritional approaches different from the others, the most effective way to reduce your risk for all of them at the same time is to improve your blood lipid profile, i.e. lower your total cholesterol, LDL and TGs, and raise HDL. Each of these changes, in turn, require specific approaches, but the most effective way to positively impact all of these blood parameters at the same time is to eliminate all partially hydrogenated fats, reduce sugar and saturated fat intake and increase unsaturated fat and dietary fiber intake.